Ketamine for depression – A Powerful but Tricky Solution

Ketamine is a very powerful anesthetic drug that’s made it’s way into psychiatry. This video explains how Ketamine can be used to treat depression.

On the streets, Ketamine is called special K. It is a hallucinogen that induces dissociation. This is a feeling of being detached from your surroundings. It is a drug that is used primarily to maintain and start anesthesia in clinical medicine.

2000 The first controlled randomized trial to test Ketamine for depression showed a rapid improvement. The FDA has not yet approved it for use in depression. We need to do more research and get more information about the safety of long-term use. Currently, we use it for IV infusions to treat depression. Recently, Spravato was approved for use in treating treatment-resistant depression. It can be used in conjunction with an antidepressant.

References
The Rapid-Acting Antidepressant Ketamine: Promising Clinical Research
Andrew N. Tuck, and Danish H. Ghazali. American Journal of Psychiatry Residents’ Journal 2017 12:3, 3-5

Canuso C., Singh J., et. al. Placebo-controlled, double-blind, randomized study on the safety and efficacy of intranasal esketamine for rapid reduction of depression and suicidality in patients at imminent risk for suicide. American Journal of Psychiatry 2018 175:7, 620-630

Grunebaum, M et. al. Midazolam-Controlled Randomized Clinical Study on Ketamine and Suicidal Thoughts: Rapid Reduction in Major Depression. American Journal of Psychiatry 2018 175:4, 327-335

Sanacora G, Frye MA, McDonald W, et al. A Consensus Statement regarding the use of Ketamine for the treatment of mood disorders. JAMA Psychiatry. 2017;74(4): 399-405.

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